Fluid Bed Granulator

Introduction

The large-scale fluid bed granulation machine is a crucial equipment in the pharmaceutical industry for the production of granules. This advanced machine utilizes fluidization technology to achieve uniform coating and drying of pharmaceutical particles, ensuring high-quality granules for further processing.

1. Fluidization Technology: This machine employs fluidization principles, where a controlled airflow lifts and suspends pharmaceutical particles in a fluidized bed. This fluidized state facilitates even distribution of heat and allows for precise control over the granulation, coating, and drying processes.
2. High Capacity Production: Designed for large-scale pharmaceutical manufacturing, this machine boasts high capacity production capabilities. It efficiently processes a significant quantity of raw materials, contributing to increased productivity and cost-effectiveness in pharmaceutical production lines.
3. Precision Granule Formation: The fluid bed granulation process in this machine ensures precise control over the size and characteristics of the granules. This is essential for achieving uniformity in drug dosage, dissolution rates, and overall product performance.

Working principle

1. Particle Fluidization: The operation initiates with the introduction of pharmaceutical particles into the machine’s chamber. Controlled airflow is applied, inducing fluidization, wherein the particles behave like a suspended fluidized bed.
2. Wetting and Nucleation: A liquid binder or solution is uniformly sprayed onto the fluidized particles, initiating wetting and nucleation. This process facilitates the binding of the liquid to the particle surfaces, starting the formation of small granules.
3. Granule Growth: Through collisions and adhesion, the wetted particles continue to grow into larger granules. The controlled conditions in the fluidized bed contribute to the desired attributes of the granules, including size, density, and porosity.
4. Drying Phase: After granule formation, the machine enters a drying phase where hot air is directed through the fluidized bed. This evaporates the liquid content from the granules, leaving behind dry and well-defined pharmaceutical granules.

Features of fluidized bed granulators?

1. Due to powder granulation, the fluidity is improved and dust is reduced; – Due to powder granulation, its solubility is improved;
2. Mixing, granulation and drying are completed in one step in the machine.
3. Using anti-static filter cloth, the equipment operates safely; – Due to the release hole, the operator will not be harmed in the event of an explosion.
4. The equipment has no dead ends. So loading and unloading is quick, light and clean. Can meet GMP requirements.

Application fluidized bed granulator

1. Widely used in pharmaceutical, chemical, food and other industries.
2. Chinese medicine granules, low-sugar or sugar-free Chinese medicine granules. Food: cocoa, coffee, milk powder, granular juice, condiments, etc. Other industries: pesticides, feed fertilizers, pigments, dyes, etc.

Technical parameters